Author Topic: Лекови, дроге и терапије будућности  (Read 67197 times)

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Meho Krljic

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Dementia tied to hormone-blocking prostate cancer treatment
 
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Alzheimer's disease may be a risk for older prostate cancer patients given hormone-blocking treatment, a large, U.S. government-funded analysis found.
 
(...)
 
 
Among 154,000 older patients, 13% who received hormone-blocking treatment developed Alzheimer's, compared with 9% who had other treatment or chose no therapy, the study found.

Meho Krljic

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Studija potvrđuje da je većinski (i to značajno većinski) uzrok autizma - nasleđivanje:
 
 
  Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort 
 
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In a large population-based multinational cohort study including more than 2 million individuals, 22 156 of whom were diagnosed with ASD, the heritability of autism spectrum disorder was estimated to be approximately 80%, with possible modest differences in the sources of autism spectrum disorder risk replicated across countries.
 
The variation in the occurrence of autism spectrum disorder in the population is mostly owing to inherited genetic influences, with no support for contribution from maternal effects.



Meho Krljic

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Menopause breakthrough will allow older women to have children after building a career, doctor claims  
 
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The revolutionary procedure, which is being offered by the fertility expert who pioneered IVF, works by tricking women’s biological clocks into thinking they are far younger than they are.
The surgery freezes ovarian tissue at -150C. It is then stored in an ice bank until women reach the menopause when it is then thawed and transplanted back into the body years later when it will then kickstart women’s natural hormones and delay the menopause.
 

Meho Krljic

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  First human-monkey chimera raises concern among scientists

Navikli smo na ovakve zaplete u naučnoj fantastici, jelte...
 

Mica Milovanovic

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Moro je malo dete za ove...  :( 
Mica


Meho Krljic

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Svako ko je imao nekog bliskog sa malignom bolešću verovatno je makar čuo savet da kupi ulje od kanabisa jer je to nezvanično dobar tretman za kancer. E, sad, ova studija ukazuje da tu ipak, uz dosta ograda, ima nečega:
 
 
   Study on cannabis chemical as a treatment for pancreatic cancer may have 'major impact,' Harvard researcher says

Meho Krljic

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Broj naučnofantastičnih zapleta koje ovo priziva je ogroman:


  Pig to human heart transplants 'possible within three years'  

Meho Krljic

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CRISPR Gene-Editing May Offer Path To Cure For HIV, First Published Report Shows 
 
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Chinese scientists have published the first report in a scientific journal of an attempt to use CRISPR-edited cells in a patient--a 27-year-old man who is HIV-positive.
While the treatment did not rid the man of the AIDS virus, the researchers and others are calling the report promising. That's because it indicates that so far the gene-editing technique seems to safely and effectively make the precise DNA change intended.
 

Meho Krljic

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Kome su fekalni transplantati već dosadni i "jučerašnji", evo priče o transplantaciji vaginalnih fluida:


Transplanting poop can be beneficial—swapping vaginal fluids may be even better


Zanimljivo zvuči i eto jednog primera inovativne zdravstvene terapije gde su žene u očiglednoj prednosti.

Meho Krljic

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Nije baš budućnost ali je zanimljivo da u Kaliforniji sada možete PrEP pilule koje preventivno deluju protiv, jelte, HIV infekcije, da kupite OTC, dakle, bez recepta.




Meho Krljic

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Baš sam pre neki dan pričao sa ćaletom o tome da sa svinja na ljude presađuju srčane zaliske (zbog sličnosti u imunosistemu itd.) a da kožu ne presađuju jer je debela, kad ono:

Surgeons Transplanted Living Pig Skin Onto Humans for the First Time





Meho Krljic

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Kad smo već kod budućnosti, male boginje, dame i gospodo, bolest koju smo praktično eliminisali a onda su se pojavili pametnjakovići sa pričama da su vakcine štetne i da su male boginje ionako sitan zdravstveni problem. Tekst je, naravno, navijačkog tipa ali objašnjava epidemiologiju, metode izračunavanja broja slučajeva i rezonovanje za kampanju vakcinisanja:
 
 
 Measles deaths 'staggering and tragic' 
 
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More than 140,000 people died from measles last year as the number of cases around the world surged once again, official estimates suggest.
Most of the lives cut short were children aged under five.
 


lilit

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  Chinese scientist who edited babies' genes jailed for three years

pored svih etičkih problema, fascinantna je arogancija i ubeđenost da će se sa trenutno postojećom tehnikom doći do vrlo specifične mutacije u CCR5, ne uzimajući u obzir da je CRISPR-Cas9 prilično specifičan al daleko od idealno specifičnog.
i naravno, dobilo se što se dobilo.
a što se tiče kineza, u zatvor su ga verovatno strpali jer nije uspeo u nameri. :lol:
btw, bila sam nedavno u pekingu na nekoj imunološkoj konferenciji, vidi se da kina ulaže ogromne pare u research. fakt je takođe i da retki pričaju, a još ređi razumeju engleski; stručna komunikacija je uglavnom teška, al za 30 godina biće to mnogo drugačije. premda, ta poslušnost koju osećaš u vazduhu je scary.
That’s how it is with people. Nobody cares how it works as long as it works.






Meho Krljic

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Evo i malo lepih vesti vezanih za viralne infekcije ovih dana:


Second person cured of HIV is still free of active virus two years on

lilit

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odličan intervju, jednostavan za razumevanje:

The Doctor Who Helped Defeat Smallpox Explains What's Coming | WIRED
https://www.wired.com/story/coronavirus-interview-larry-brilliant-smallpox-epidemiologist/
That’s how it is with people. Nobody cares how it works as long as it works.

lilit

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jako lep video za pokazati deci:

https://www.youtube.com/watch?v=_kU4oCmRFTw
That’s how it is with people. Nobody cares how it works as long as it works.

lilit

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prekjuče webinar, vienna organized, first hand experience italijanskih lekara. bitno za sve lekare koji će doći u susret s inficiranim:

FREE WEBINAR Covid – 19 – The Italian experience – What should we be prepared for?

 https://www.123sonography.com/covid-19-webinar
That’s how it is with people. Nobody cares how it works as long as it works.

lilit

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evo jednostavnog videa (nažalost na nemačkom, al prosto je) kako treba da bude zaštićen medical staff (ne građani!) koji tretiraju covid-19 pacijente:

https://www.youtube.com/watch?v=Xj2AVCkipFk&feature=youtu.be
That’s how it is with people. Nobody cares how it works as long as it works.

lilit

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odličan i vrlo jednostavan tekst:

Coronavirus: The Hammer and the Dance


https://medium.com/@tomaspueyo/coronavirus-the-hammer-and-the-dance-be9337092b56
That’s how it is with people. Nobody cares how it works as long as it works.

lilit

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 detaljnije o hlorokinu:
 
Insights from nanomedicine into chloroquine efficacy against COVID-19
 
https://www.nature.com/articles/s41565-020-0674-9?utm_source=twitter&utm_medium=social&utm_content=organic&utm_campaign=NGMT_USG_JC01_GL_NRJournals
 
That’s how it is with people. Nobody cares how it works as long as it works.

lilit

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ekskluzivno za sagitu :)
u organizaciji moje "firme"

 Shanghai - Vienna - Paris - Dallas
 
FREE WEBINAR:
COVID-19 - Protection - Management - POCUS
 27th March 2020
5PM CET / 11AM CDT


https://www.123sonography.com/covid-19-webinar?utm_source=123sonography&utm_campaign=a4e7392330-msk-ugi-webinar_COPY_01&utm_medium=email&utm_term=0_879e084a1d-a4e7392330-423618785


samo kliknite na link večeras u 17h. verujem da će biti puno relevantnih informacija.


That’s how it is with people. Nobody cares how it works as long as it works.

džin tonik

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nevjerojatno kako juzna koreja konkretno barata sa epidemijom, kako umrezili tehnologiju. taj vas webinar nije za obicne smrtnike, previse serioznih informacija.

lilit

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nevjerojatno kako juzna koreja konkretno barata sa epidemijom, kako umrezili tehnologiju. taj vas webinar nije za obicne smrtnike, previse serioznih informacija.

južna koreja je top. 360.000 testiranja odrađeno, 139 mrtvih. virus sateran u ćošak. fascinantno.
koliko su samo naučili nakon sarsa 2012.
i sve to, izuzetno bitno naglasiti, bez vojnih mera koje je kina primenila.
That’s how it is with people. Nobody cares how it works as long as it works.

scallop

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Samo molim da mi se ne zameri. Unuka mi jesenji semestar provela u J. Koreji. Jedva su je izvukli iz sledećeg u Japanu. Pitao sam jel' osetila PARASITE. Pojma nema.
Never argue with stupid people, they will drag you down to their level and then beat you with experience. - Mark Twain.

džin tonik

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južna koreja je top. 360.000 testiranja odrađeno, 139 mrtvih. virus sateran u ćošak. fascinantno.
koliko su samo naučili nakon sarsa 2012.
i sve to, izuzetno bitno naglasiti, bez vojnih mera koje je kina primenila.

kini ne vjerujem nista ni kad kaze dobar dan, posebno od kad se stvarno bakcu s tim virusom. ali jk je ocigledno dala dobru smjernicu, nijemci su testirali nekih 500k, a zadnja dva dana se razmislja u tom pogledu jos i intenzivno podici kapacitete (ali to vise u pravcu deeskalacije mjera, moguce sveobuhvatno krecu i u potragu za antitijelima, postotkom imunizacije).

lilit

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ni ja ne verujem da su kinezi izneli sve podatke, al to je nemoguće dokazati/opovrgnuti.

što se tiče antitela, biće zanimljivo videti da li serologija (antitela) prati modeling tzv. oxford studije: https://www.medrxiv.org/content/10.1101/2020.03.24.20042291v1
jeste da studija nije peer-reviewed al bi sigurno prošla ozbiljan peer-review (a danas nema vremena da se čeka 2 meseca minimum da ti pošalju komentare nazad).

biće zanimljivo videti i švedski eksperiment, oni su polako krenuli sa herd immunity pristupom.
That’s how it is with people. Nobody cares how it works as long as it works.

Meho Krljic

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Koliko ja shvatam, Šveđani i testiraju značajno manje slučajeva nego ostali u Evropi pa prosto ne znam da li ćemo uopšte moći da poredimo cifre koje imaju oni sa, npr. nemačkim ili slovenačkim. Nadam se da njihovi epidemiolozi imaju neku matematiku koja će pomoći da se vidi nekakva slika približno "stvarna" kao kod ostalih.

džin tonik

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ja sam skoro otishao u teorije zavjere, jer, subjektivno, dugo nije bilo ozbiljnijeg spomena antitijela u medijima.
dobro da je info bitan za izlaznu strategiju, pa nezaobilazno; sad ako taj modeling utemeljen, mogla bi se dobiti realna povijest razvoja.

mac

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    • http://www.facebook.com/mihajlo.cvetanovic
Meni se čini kao odlična ideja da oni koji su mladi i zdravi, i kojima se ne predviđaju loše posledica prilikom zaraze, da se zaraze i izoluju planski. Kako kad šumari vatru gase vatrom.

lilit

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Koliko ja shvatam, Šveđani i testiraju značajno manje slučajeva nego ostali u Evropi pa prosto ne znam da li ćemo uopšte moći da poredimo cifre koje imaju oni sa, npr. nemačkim ili slovenačkim. Nadam se da njihovi epidemiolozi imaju neku matematiku koja će pomoći da se vidi nekakva slika približno "stvarna" kao kod ostalih.

imaćemo stvarnu epidemiološku sliku čim dobijemo reliable serološki test i nadam se da će to biti najkasnije za tri nedelje. moraćemo da testiramo SVE (neko će ogromne pare da zaradi na testovima) i videćemo koliko smo prokuženi (po različitim državama, al porediće se broj koji imaju protection). NEVEROVATNA SREĆA je što ovaj virus zahteva samo da trigerujemo antitela da bismo ga se rešili, ne moramo da se akamo sa stimulacijom celularnog imunskog odgovora. to bi bila unapred izgubljena bitka.  :mrgreen:
That’s how it is with people. Nobody cares how it works as long as it works.

lilit

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ja sam skoro otishao u teorije zavjere, jer, subjektivno, dugo nije bilo ozbiljnijeg spomena antitijela u medijima.
dobro da je info bitan za izlaznu strategiju, pa nezaobilazno; sad ako taj modeling utemeljen, mogla bi se dobiti realna povijest razvoja.

da, da, lepo je videti da te drosten vratio na pravi put. :mrgreen: :lol:
That’s how it is with people. Nobody cares how it works as long as it works.

lilit

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Meni se čini kao odlična ideja da oni koji su mladi i zdravi, i kojima se ne predviđaju loše posledica prilikom zaraze, da se zaraze i izoluju planski. Kako kad šumari vatru gase vatrom.

krasna ideja. šta kažu mladi na to? :mrgreen:

predviđanja u medicini (i biologiji in general) nisu kao u matematici ili sličnim disciplinama. ko bi svesno izložio celu populaciju virusu o kome, još uvek, ne znamo dovoljno, a vidimo i da mladi ljudi nisu 100% imuni? niko, nadam se.

https://www.thelocal.fr/20200327/what-we-know-about-frances-youngest-coronavirus-victim
That’s how it is with people. Nobody cares how it works as long as it works.

lilit

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 TOP!
It’s a revolution: ramp-up in safer coronavirus testing

 
That’s how it is with people. Nobody cares how it works as long as it works.