Лекови, дроге и терапије будућности

[Meho Krljic]

Pig heart transplant failure: Doctors detail everything that went wrong

[Meho Krljic]

We Might Be Treating Schizophrenia All Wrong

A new study run by researchers in Japan and published earlier this year in Cell Reports Medicine suggests that for at least a significant portion of patients, the immune system is mistakenly attacking a protein in the brain—which may be the real mechanism giving rise to schizophrenic symptoms in the first place.

[Meho Krljic]

Scientists create synthetic mouse embryos, a potential key to healing humans

Stem cell researchers in Israel have created synthetic mouse embryos without using a sperm or egg, then grown them in an artificial womb for eight days, a development that opens a window into a fascinating, potentially fraught realm of science that could one day be used to create replacement organs for humans.The objective, scientists involved with the research said, is not to create mice or babies outside the womb, but to jump-start the understanding of how organs develop in embryos and to use that knowledge to develop new ways to heal people.

[Meho Krljic]

Newly Discovered Molecule Fights Off Over 300 Kinds of Drug-Resistant Bacteria

[Meho Krljic]

A Biochemist's View of Life's Origin Reframes Cancer and Aging

[Meho Krljic]

Common lab molecule surprises researchers with potential cancer-fighting properties

[Meho Krljic]

'Miracle' herpes treatment eradicates tumours in terminally-ill cancer patients  

  Terminally-ill cancer patients have seen their tumours completely eradicated or shrunk after being treated with a genetically-engineered version of the herpes virus.
Scientists at the Institute for Cancer Research in London have developed a new therapy which infects and destroys cancer cells while also rallying the immune system.
In early trials to assess the safety of the therapy, one quarter of patients with end-of-life cancer saw their tumours stop growing, shrink or disappear completely.
Krzysztof Wojkowski, 39, a builder from West London who had no treatment options left after developing a salivary gland tumour, has been cancer-free for two years since taking part in the trial at the Royal Marsden in London in 2020.
"I was told there were no options left for me and I was receiving end of life care," he said. 


   "I had injections every two weeks for five weeks which completely eradicated my cancer.
"I've been cancer-free for two years now, it's a true miracle, there is no other word to describe it. I've been able to work as a builder again and spend time with my family, there's nothing I can't do."
    Virus causes cancer cells to burst The genetically engineered virus - called RP2 - is injected directly into the tumour where it multiplies, causing cancer cells to burst from within.
It also blocks a protein called CTLA-4 which dials down the immune system, and so gives the body more of a chance to fight off the cancer. In addition, the virus also produces molecules which spark the immune system into action against cancer.
The therapy was tested on 39 patients with cancers including skin, oesophageal and head and neck cancer who had exhausted all other treatments.
Results showed that around one quarter saw a benefit.
The herpes simplex virus is a common infection, which many people already carry latently without problems.
Researchers looked at patient biopsies before and after RP2 injections and found positive changes in the tumour's "immune microenvironment" – the area immediately around the tumour. Injections led to more immune cells in the area, including CD8+ T-cells, and "switched on" genes linked to the "anti-cancer" immune response.
The team found that most side effects of RP2 were mild – some of the most common were fever, chills, and fatigue. None of the side effects were serious enough to require medical intervention.
Professor Kristian Helin, chief executive of The Institute of Cancer Research, London, said: "Viruses are one of humanity's oldest enemies, as we have all seen over the pandemic. But our new research suggests we can exploit some of the features that make them challenging adversaries to infect and kill cancer cells.
"It's a small study but the initial findings are promising. I very much hope that as this research expands we see patients continue to benefit."
Potential to become new treatment option Study leader Kevin Harrington, professor of biological cancer therapies at The Institute of Cancer Research, said: "Our study shows that a genetically engineered, cancer-killing virus can deliver a one-two punch against tumours – directly destroying cancer cells from within while also calling in the immune system against them.
"It is rare to see such good response rates in early-stage clinical trials, as their primary aim is to test treatment safety and they involve patients with very advanced cancers for whom current treatments have stopped working.
"Our initial trial findings suggest that a genetically engineered form of the herpes virus could potentially become a new treatment option for some patients with advanced cancers – including those who haven't responded to other forms of immunotherapy.
"I am keen to see if we continue to see benefits as we treat increased numbers of patients."
The research was presented at the 2022 European Society for Medical Oncology Congress (ESMO), and the team are hoping to move to bigger trials.

[Meho Krljic]

New Discovery Can Kill COVID With 'Hugs'—but There's a Catch

[Meho Krljic]

A psychiatry researcher who taught his students depression was caused by a 'chemical imbalance' in the brain says everything he thought he knew about SSRIs is wrong

[Meho Krljic]

 Pfizer's RSV vaccine for pregnant women protects newborns against severe illness

[Meho Krljic]

 Psychedelic mushroom dose can treat stubborn depression, trial suggests

[Meho Krljic]

 Fentanyl vaccine developed by researchers could eliminate drug's 'high'

[Meho Krljic]

   Vaccine shown to prolong life of patients with aggressive brain cancer

[Meho Krljic]

   Universal flu vaccine may be available within two years, says scientist

[Meho Krljic]

 New data shows Alzheimer's drug can slow cognitive decline

[Meho Krljic]

Base editing: Revolutionary therapy clears girl's incurable cancer

[Meho Krljic]

Moderna says personalized mRNA cancer vaccine is effective for advanced melanoma  

The company said that in a phase 2 clinical trial, the vaccine, when combined with immunotherapy drug Keytruda, reduced the risk of recurrence by 44%. 

[Meho Krljic]

Scientists Have Reached a Key Milestone in Learning How to Reverse Aging

[Meho Krljic]

Nije baš lek i nije budućnost ali close enough:

Maybe rats didn't spread the Black Death after all, new evidence suggests

[Meho Krljic]

Australia to allow prescription of MDMA and psilocybin for treatment-resistant mental illnesses

[Meho Krljic]

Anti-ageing scientists extend lifespan of oldest living lab rat

Scientists working on an experimental anti-ageing therapy claim to have broken a record by extending the lifespan of a lab rat called Sima.
Named after the Hindi word for "limit" or "boundary", Sima is the last remaining survivor from a group of rodents that received infusions of blood plasma taken from young animals to see if the treatment prolonged their lives.Sima, who was born on 28 February 2019, has lived for 47 months, surpassing the 45.5 months believed to be the oldest age recorded in scientific literature for a female Sprague-Dawley rat, the researchers say. So far, Sima has outlived her closest rival in the study by nearly six months.

[Meho Krljic]

 Sugar-powered teabag-like implant successfully manages type 1 diabetes

[Meho Krljic]

Cancer and heart disease vaccines 'ready by end of the decade'

[Aco Popara Zver]

đe lilit

na sve strane pričaju da je kreatin dobar, zdrav itd... nešto sam sumnjičav prema tome, ipak mi nije logično, više da fitnes industrija fura priču da bi prodavala

slušam samo lilit, ako se pojavi na Sagiti uopšte...

[tomat]

Ja imam problem sa aritmijama, naišao sam da bi kreatin trebalo da izbegavam, nije da sam planirao da ga uzimam svakako

Sa druge strane, poručio taurin i l-arginin jer mogu da pomognu kod aritmija, a onda vidim da ih i badibilderi cene, zbog drugih stvari naravno, nije baš rasprostranjeno u prodaji al vidim da ga nude ove radnje što nude suplemente za u teretanu.

[Aco Popara Zver]

većinom od ozbiljnih ljudi slušam da ne valja

ali sad Huberman preporučuje

[Meho Krljic]

Experimental vaccine shows promise in delaying the return of aggressive brain tumor

[Meho Krljic]

Drug donanemab seen as turning point in dementia fight

[Meho Krljic]

NEW STUDY: Discovery of Chemical Means to Reverse Aging and Restore Cellular Function

[Meho Krljic]

Mysterious case of the 'Geneva patient,' the latest person in long-term remission from HIV, raises questions

[Meho Krljic]

Duža konzumacija kanabisa i promene u epigenomu:


https://www.nature.com/articles/s41380-023-02106-y

In conclusion, we observed significant associations between recent and cumulative marijuana use with DNA methylation markers across time. We also observed cis-meQTLs and DMRs associated with marijuana use and biologically relevant pathways and diseases, suggesting potential shared genes between marijuana use and cellular proliferation, hormone signaling, and mental disorders. Additional studies are needed to replicate and verify the observed associations presented here. With the greater number of states legalizing marijuana for medical and recreational use, as well as the expected rise in its use, examining the association between marijuana and the epigenome may aid in elucidating the molecular and biological processes influencing downstream health conditions and may serve as potential biomarkers to identify recent and long-term marijuana use and intervene in the early stages of their related health outcomes.

[Meho Krljic]

Scientists Intrigued by Clever Trick That Makes Cancer Cells Self-Destruct

[Meho Krljic]

An Aging Expert Thinks Humans Can Live for 20,000 Years. He's Not Crazy.

Naravno, sve je ovo teorija, jelte, na dugačkom štapu ali me jeste ponukalo da razmišljam, kada bismo zaista pristup terapiji koja popravlja svu štetu na DNK i zaustavlja starenje ćelija, kako bismo onda tretirali gubitak života u saobraćajnoj nesreći ili ubistvo? Verovatno bi nam stil života bio DRASTIČNO promenjen već i time što bismo na smrt gledali kao na izuzetak a ne pravilo.

[tomat]

Kruciforma?

[Meho Krljic]

Ha! Kruciforma je mnogo dramatilniji koncept, ona te oživljava kad umreš, dok ovo o čemu ovaj čovek priča opravlja ćelije i DNK tako de NE UMREŠ!!!!!!!!!!

[Meho Krljic]

Da se Lilita pod hitno vrati da malo pogleda ovaj rad o oralnoj terapiji za maligne bolesti o kojem se bruji poslednjih par dana i da da svoje mišljenje:


https://www.cell.com/cell-chemical-biology/pdfExtended/S2451-9456(23)00221-0

[Meho Krljic]

Dijabetes tipa 2 se može uspešno tretirati... parazitskim crvima:


Effect of experimental hookworm infection on insulin resistance in people at risk of type 2 diabetes

[Onaj stari Sendmen]

Dijabetes tipa 2 se može uspešno tretirati... parazitskim crvima:


Effect of experimental hookworm infection on insulin resistance in people at risk of type 2 diabetes

I heroin je bio lek. 

[Aco Popara Zver]

đe lilit

na sve strane pričaju da je kreatin dobar, zdrav itd... nešto sam sumnjičav prema tome, ipak mi nije logično, više da fitnes industrija fura priču da bi prodavala

slušam samo lilit, ako se pojavi na Sagiti uopšte...

4 mjeseca bez kreatina!

[lilit]

the future is here

https://www.scientificamerican.com/article/weight-loss-drug-wegovy-slashes-risk-of-death-in-some-people-with-heart-disease/?utm_campaign=socialflow&utm_source=twitter&utm_medium=social

[Aco Popara Zver]

odlično, napokon prava stvar, krkaš a mršaš

još nam treba

1. neka droga da diže iz mrtvih (imunitet, koncentraciju, snagu itd)

2. nešto protiv ćelavljenja

[lilit]

nekad je jelena radulović radila u centru za imunološka istraživanja na torlak hillu. ovo je revolucija u neuroimunologiji 

DNA Damage and Inflammation Key to Memory Formation

Researchers uncovered that the formation of long-term memories hinges on processes traditionally viewed negatively: DNA damage and brain inflammation.

The research demonstrates that specific neurons in the hippocampus, the brain's memory center, require activation of the inflammatory Toll-Like Receptor 9 (TLR9) pathway following DNA damage to form memory clusters.

This inflammation-driven mechanism, contrary to causing neurological issues, is essential for encoding experiences.

The study challenges the traditional perspective on neuroinflammation, underscoring its necessity in memory formation and signaling a paradigm shift in how we understand brain health and disease, with implications for treating conditions like Alzheimer's and considerations for therapies targeting the TLR9 pathway.
A study reveals brain inflammation and DNA damage are crucial for forming long-term memories, challenging our views on neuroinflammation.
https://www.nature.com/articles/s41586-024-07220-7

[Meho Krljic]

Sa malim zakašnjenjem evo nešto o najnovijem dostignuću na polju borbe protiv HIV-a:

HIV cure breakthrough as virus eliminated from cells in laboratory

[mac]

Neki lik se natčovečno bori za naše opšte zdravlje. Intervju s njim traje 1h 45'

World No.1 Biohacking Expert: I Tested 100,000 People's DNA. This Diet Will Kill You - Gary Brecka

[Meho Krljic]

Welcome to the Age of Psychedelic Inequality


O dostupnosti psihodelika u terapijama s obzirom na njihovu cenu. Nisam ni znao da su ovakve terapije i kod nas već dostupne, a jesu.

[mac]

Alchajmer je možda posledica nedostatka amino kiseline L-serin koja nas čuva od amino kiseline BMAA koju proizvode neke cijanobakterije. Neki doktor iz američkog budžaka je pronašao vezu, i to se sad dalje istražuje.

How a Medical Mystery in Guam Led to a New Approach to Alzheimer's Disease

[Meho Krljic]

Humans May Be Able to Grow New Teeth Within Just 6 Years 


Ovo "within just six years" znači da japanski istraživači svoju predloženu terapiju trenutno testiraju i da se nadaju da uđe u opštu upotrebu do 2030. godine.

[12]

poceo sam i da pijem. popijem pred rucak casicu rakije. to ranije nisam cinio

[Meho Krljic]

Jel' to lek, droga ili terapija?

[12]

sve to, nekako