ZNAK SAGITE — više od fantastike — edicija, časopis, knjižara...

  Autoimmune diseases: we discovered how to turn white blood cells from attacking the body to protecting it

Diluting blood plasma rejuvenates tissue, reverses aging in mice

Ne da je ovo sad neko iznenađenje...

CRISPR gene editing in human embryos wreaks chromosomal mayhem

moram da podelim sledeću fascinaciju sa cenjenim sagita odijensom: shvatila sam da ogroman broj lekara (a verovatno i ostatak ljudske populacije) smatra da imamo efikasnu vakcinu protiv tuberkuloze.
e pa nemamo.
postojeća vakcina štiti protiv TB meningitisa (u 60-80% slučajeva) koji se javlja kod dece, al slabo štiti bolje rečeno ne štiti protiv respiratornog oblika tuberkuloze koji se primarno manifestuje kod odraslih osoba. meaning: to što ste primili BCG vakcinu vas 99% neće zaštititi od respiratorne tuberkuloze. sreća pa postoje efikasni lekovi, premda već cirkulišu sojevi Mycobacterium tuberculosis koji su rezistentni na postojeće lekove.

QuoteTuberculosis (TB) remains as an important infectious disease and public health concern worldwide. According to the latest World Health Organization (WHO) report, there were an estimated 8.6 million incident cases of TB in 2012 and 1.3 million deaths were attributed to the disease. More than half a million cases occurred in children and 320,000 deaths were reported among HIV-infected persons [1]. However, even more disturbing is the emergence of drug resistance. In 2012, there were an estimated 450,000 cases of multidrug resistant (MDR)-TB and 170,000 deaths were due to it. MDR-TB is caused by strains of Mycobacterium tuberculosis that are resistant to at least rifampicin and isoniazid, two key drugs in the treatment of the disease. Since 2006, it has been recognized the presence of even more resistant strains of M. tuberculosis labelled as extensively drug resistant (XDR)-TB [2,3,4]. These strains in addition to being MDR are also resistant to any fluoroquinolone and to at least one of the injectable second-line drugs: kanamycin, capreomycin or amikacin. More recently, a more worrying situation has emerged with the description of M. tuberculosis strains that have been found resistant to all antibiotics that were available for testing, a situation labelled as totally drug resistant (TDR)-TB [5,6,7]. Early detection of all forms of drug resistance in TB is a key factor to reduce and contain the spread of these resistant strains.

btw, čisto kao crtica: trenutno imamo (licencirane) vakcine protiv 26 infektivnih bolesti. SAMO 26.

Experimental Blood Test Detects Cancer up to Four Years before Symptoms Appear

Možda će anti-vakseri konačno da se smire. Ha.

Early neural activity associated with autism

Evo, jedne lepe vesti:

Africa declared free of wild polio in 'milestone'

Naravno, isključivi razlog što je ovo postignuto je da je vakcina razvijena i učinjena dostupnom uz velike napore (članak govori o tome kako je nigerijska vlada uložila mnogo truda da dosegne udaljene oblasti u kojima se, pa, puca),a verovatno ćemo za par decenija slušati nigerijske antivaksere kako vrište da je vakcina prevara, izaziva autizam itd.

Oregon Becomes First State To Legalize Psychedelic Mushrooms

A new drug cocktail could help fight the toughest cancers

It Sure Looks Like Humans Have Found a Way to Reverse Aging

Quote from: Meho Krljic on 20-11-2020, 07:44:11
It Sure Looks Like Humans Have Found a Way to Reverse Aging

nije dovoljno samo produžiti telomere, najbitnije je sprečiti mutacije koje mogu odvesti kanceru te verujem da se radi i na tome. but who wants to live forever?

Evo ja.

 MDMA-assisted couples therapy investigated in landmark pilot trial

A sad:


Drug Reverses Age-Related Mental Decline Within Days

Naravno, tekst ne daje link do samog rada pa je jasno da malo pumpa hajp...

Viagra may help men to live longer and reduce their risk of heart disease, study finds

 Scientists Create Simple Synthetic Cell That Grows and Divides Normally

The genetic mistakes that could shape our species

Harvard scientists create gene-editing tool that could rival CRISPR

HIV/AIDS vaccine: Why don't we have one after 37 years, when we have several for COVID-19 after a few months?   

 Researchers claim they have sequenced the entirety of the human genome — including the missing parts

  HIV vaccine trial starts at Oxford

  Weed withdrawal: More than half of people using medical cannabis for pain experience withdrawal symptoms

Moderna to start testing new HIV vaccines

The Plan to Stop Every Respiratory Virus at Once

2021. godina je i konačno imamo vakcinu protiv malarije?

WHO recommends groundbreaking malaria vaccine for children at risk

Quote from: Meho Krljic on 07-10-2021, 17:28:54
2021. godina je i konačno imamo vakcinu protiv malarije?

WHO recommends groundbreaking malaria vaccine for children at risk

nemamo. al biće ok u kombinaciji sa insekticidima, mrežama i anti-falciparum medikamentima.

o toj vakcini smo već (minimalnmo) pisali na sagiti
http://www.znaksagite.com/diskusije/index.php?topic=13839.msg733000#msg733000

A sad i tretman za rak (makar, jelte, probno). 2021. godina donosi neke lepe nove prodore:


    New treatment destroys head and neck cancer tumours in trial

U.S. surgeons successfully test pig kidney transplant in human patient

Quote from: Meho Krljic on 22-10-2021, 05:55:50
U.S. surgeons successfully test pig kidney transplant in human patient

Mnogima u našem narodu  propada poslednja odstupnica ovom vešću. Prodaja bubrega kao izlaz iz finanijske krize.  Vreme je strpljivo, i ponekad ga sažaljevam jer će morati da istrpi sebe i svoju prolaznost kako bi i sebi i nama pokazalo da li je ova revolucija razmene svinjskog bubrega za ljudski stvarna ili samo omaž valjanju belih bubrega za crne. 

Jel čipovan bubreg?

Sutra Vučić objavljuje saradnju Neoplante i VMA.

Jedino što Neoplanta nema ni farme ni njesvi. Sve uvoz bajo moj. + mora bude špricana svinja, više mi je to saradnja na relaciji - Torlak za špricanje sa licencom Pfizera, Tesla za čipove, neka domaća farma svinja,  glavni finansijer i nadzorni organ naravno Vanguard, Vučić je PR i seče vrpce  i valja bubrege po regionu ako se dobro pokažu kod nas! Al ' mora ima Ivermectin free sertifikat, Nestorović polud'o kad čuo..

Okle će sveže meso duvoze, valjda suhomesnato je Argentina? Pokvarile bi se sveže butkice, a tek bubrezi.

Hladni lanac.

 Giant Study Finds Viagra Is Linked to Almost 70% Lower Risk of Alzheimer's

A ima i ovo:

Older people who get cataracts removed have lower dementia risk

Hjudž if čru, što bi rekli u Engleskoj:


Scientists Find a Natural Protein That Stops Allergies And Autoimmune Conditions

Psychedelic frees up depressed brain, study shows 

Quote
   Psilocybin, a drug found in magic mushrooms, appears to free up the brains of people with severe depression in a way that other antidepressants do not, a study has found. 

Океј су студије, али псилоцибин је алкалоид. Тако да људи, немојте се дрогирати без одобрења лекара или фармацеута!

Dobro, i nikotin i kofein i tein su alkaloidi, ne verujem da ćeš tim podatkom da prepadneš zainteresovanu populaciju 
Ali naravno da sam i ja za odgovorno korišćenje hemikalija, makar bile i "prirodne".

"In rats, the median lethal dose (LD50) when administered orally is 280 milligrams per kilogram (mg/kg), approximately one and a half times that of caffeine. When administered intravenously in rabbits, psilocybin's LD50 is approximately 12.5 mg/kg. Psilocybin comprises approximately 1% of the weight of Psilocybe cubensis mushrooms, and so nearly 1.7 kilograms (3.7 lb) of dried mushrooms, or 17 kilograms (37 lb) of fresh mushrooms, would be required for a 60-kilogram (130 lb) person to reach the 280 mg/kg LD50 value of rats. Based on the results of animal studies, the lethal dose of psilocybin has been extrapolated to be 6 grams, 1000 times greater than the effective dose of 6 milligrams. The Registry of Toxic Effects of Chemical Substances assigns psilocybin a relatively high therapeutic index of 641 (higher values correspond to a better safety profile); for comparison, the therapeutic indices of aspirin and nicotine are 199 and 21, respectively. The lethal dose from psilocybin toxicity alone is unknown at recreational or medicinal levels, and has rarely been documented—as of 2011, only two cases attributed to overdosing on hallucinogenic mushrooms (without concurrent use of other drugs) have been reported in the scientific literature and may involve other factors aside from psilocybin."

17 кила печурака за овердоуз.   

Rejuvenation of woman's skin could tackle diseases of ageing 

Quote
   Researchers have rejuvenated a 53-year-old woman's skin cells so they are the equivalent of a 23-year-old's.   The scientists in Cambridge believe that they can do the same thing with other tissues in the body.   The eventual aim is to develop treatments for age-related diseases such as diabetes, heart disease and neurological disorders.   The technology is built on the techniques used to create Dolly the cloned sheep more than 25 years ago. 

(...)

The technique cannot immediately be translated to the clinic because the IPS method increases the risk of cancers.

Massive DNA study of human cancers offers new clues about their causes 

Quote
Team leader Professor Serena Nik-Zainal said this is the largest study of its kind and that the vast amount of data her team worked with allowed them to detect patterns in the genetic alterations or "mutational signatures" found in the tumors. By comparing their results with other studies, they were able to confirm that 58 of the mutational signatures they found were previously unknown. Some of them are pretty common, while some are rare.

MIT scientists found a way to reverse hearing loss that may be as easy as Lasik

 First human patient injected with revolutionary cancer-killing virus

Gdje nam je lilit da kaže koju o hpv vakcini

Da prime tinejdžeri pretpostavljam

Jebote napisala je to bar 5-6 puta za svoga staža na Sagiti. Naravno da prime, kakve tu uopšte dileme ima???

Whada mistaka to maka!

The 'Benjamin Button' effect: Scientists can reverse aging in mice. The goal is to do the same for humans

Treatment uses patient's own immune system to wipe out 100% of rectal cancer in recent trial

'It can create life': Chinese team claim stem cell breakthrough in mice study  

Quote
Chinese scientists say they have found a way to reprogram stem cells so they have potential to generate an entire organism.

Dženesis divajs

https://youtu.be/GnziufszqSE